Open and distance learning is aimed at fostering equitable access, participation, and success for diverse learners within digital learning environments. This study seeks to investigate inclusive digital learning in-ecosystems in National Open University of Nigeria (NOUN): Policies and practice. The study is a survey that utilized structured questionnaire to generate information from 300 participants comprising NOUN students selected through stratified random sampling from the six geopolitical zones of Nigeria. Data analysis involves the use of SPSS version 25 to run frequencies and percentages for the research questions while for the hypothesis s a correlation coefficient statistic (p<0.5). Findings showed (33.3%) that NOUN offers alternative formats for study materials for students with specific needs. The study also revealed (50.0%) that NOUN promotes awareness and understanding of inclusivity in the digital learning environment among students and faculty members. Also, the findings of the study indicated that non- availability of assistive technologies and in particular not having their course materials in braille were major challenges. The study recommended creating awareness and training of lecturers and students on how to use assistive technologies for policymakers, educators, and stakeholders to advance inclusive digital learning ecosystems, emphasizing the importance of policies and practices evaluations of distance and e-learning in the Nigerian ecosystems.